PD-L1 Expression is Associated with Grade of Neuroendocrine Tumors

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Introduction: Neuroendocrine neoplasms are divided into well-differentiated neuroendocrine tumors (WDNETs) and poorly differentiated neuroendocrine carcinomas (PDNECs).The correlation between Gastroenteropancreatic Neuroendocrine Neoplasms (GEPNENs) and immunocheck point molecule-PD-L1 is still unclear now.

Aim(s): This study want to explore the relationship between PD-L1 expression and clinical-pathological parameters of GEPNENs.

Materials and methods: Totally 59 GEPNENS patients who received surgery were involved in this study. The patients included 21 cases from stomach (4 WDNETs and 17 PDNECs), 2 cases from duodenum (2 PDNECs), 8 cases from colon (8 PDNECs), 4 cases from rectum (4 PDNECs), and 24 cases from pancreas (10 WDNETs and 14 PDNECs).PD-L1 expression was detected by Immunohistochemistry on Tissue Microarray(TMA) of these cases.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Leng J

Authors: Li Z, Leng J, Wang H, Li S, Lu M,

Keywords: PD-L1, neuroendocrine tumor, grade,