Phase 1 Expansion Study of an Oral TORC1/TORC2 Kinase Inhibitor (CC-223) in Non-Pancreatic Neuroendocrine Tumors (NET) Abstract #869

Introduction: Clinical efficacy of everolimus, an allosteric TORC1-selective inhibitor, has been established in pancreatic NET. CC-223 is an ATP-competitive inhibitor of the mTOR kinase, inhibiting both TORC1 and TORC2.
Aim(s): To evaluate clinical activity of CC-223 in NET.
Materials and methods: After establishing MTD, subjects with non-pancreatic NET on somatostatin analogues (SSA) and progressing within 12 months were enrolled in an expansion cohort of CC-223 at 45mg QD in 28-day cycles.
Conference: 11th Annual ENETS Conference 2014 (2014)
Category: Medical treatment - Targeted therapies
Presenting Author: Professor Tim Meyer
Keywords: TORC-1 CC-223

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