Phase 1 Expansion Study of an Oral TORC1/TORC2 Kinase Inhibitor (CC-223) in Non-Pancreatic Neuroendocrine Tumors (NET)
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Introduction: Clinical efficacy of everolimus, an allosteric TORC1-selective inhibitor, has been established in pancreatic NET. CC-223 is an ATP-competitive inhibitor of the mTOR kinase, inhibiting both TORC1 and TORC2.
Aim(s): To evaluate clinical activity of CC-223 in NET.
Materials and methods: After establishing MTD, subjects with non-pancreatic NET on somatostatin analogues (SSA) and progressing within 12 months were enrolled in an expansion cohort of CC-223 at 45mg QD in 28-day cycles.
Conference: 11th Annual ENETSConcerence (2014)
Presenting Author:
Authors: Meyer T, Mahipal A, Bendell J, Nemunaitis J, Mita M,
Keywords: TORC-1 CC-223,
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