Platelet Serotonin But Not Dopamine Concentrations Are Lower in Pancreatic Neuroendocrine Tumor and Renal Cell Carcinoma Patients Compared to Healthy Individuals.

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Introduction: Platelets carry VEGF-A, serotonin and dopamine. Serotonin stimulates and dopamine inhibits tumor angiogenesis. We hypothesized that platelets are activated in tumor vasculature and release angiogenic factors, resulting in lower platelet serotonin and dopamine.

Aim(s): To compare platelet biogenic amine levels in pancreatic neuroendocrine tumor (pNET) and renal cell carcinoma (RCC) patients with controls and to explore a possible correlation between platelet biogenic amine and VEGF-A levels.

Materials and methods: In a cross-sectional case control study, serotonin and dopamine levels were analyzed in platelet rich and platelet poor plasma of metastatic pNET and RCC patients and controls using high performance liquid chromatography-tandem mass spectrometry. Platelet VEGF-A was analyzed with ELISA.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Peters M, Van Faassen M, Van Asselt S, Bouma G, Meijer C,

Keywords: Serotonin, dopamine, pancreatic neuroendocrine tumor, renal cell carcinoma.,