Poorly Differentiated Neuroendocrine Carcinomas of the Colon: A Clinicopathological Study

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Introduction: Neuroendocrine carcinomas (NEC) of the colon and rectum are aggressive and rare tumours. The Digestive Tract WHO classification 2010 defines the entity of large cell NEC (LCNEC) in contrast to small cell NEC (SCNEC).

Aim(s): This study provides a meticulous characterization of LCNEC with regard to clinicopathological aspects.

Materials and methods: Over a period of four years 455 patients with colorectal cancer (CRC) have been undergone surgery in two huge tumour centers. After immunhistochemical staining with specific neuroendocrine markers they have been subdivided in three subgroups of high grade neuroendocrine neoplasms (high grade NEN): LCNEC, SCNEC and mixed adenoneuroendocrine carcinomas (MANEC). These were further characterized by 16 immunohistochemical stains and molecular markers.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Boeck I

Authors: Boeck I, Weihe E, Krieg A, Gabbert H, Raffel A,

Keywords: GEP-NEC, LCNEC, Colonic NEC,