Potential Role of SST5TMD4-Derived Peptides in the Malignancy of Neuroendocrine Tumors and Other Endocrine-Related Cancer Cells

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Introduction: Extracellular fragments derived from membrane receptors can play relevant functional roles in certain tumoral pathologies and could provide novel diagnostic or therapeutic tools. We have identified a novel truncated somatostatin receptor type 5 variant, sst5TMD4, which is overexpressed and functionally active in different endocrine-related cancers, including neuroendocrine tumors (NETs). Interestingly, sst5TMD4 has 4 transmembrane domains and its C-terminal tail is consequently exposed towards the extracellular matrix, and could, therefore, be the substrate for proteolytic enzymes.

Aim(s): -

Materials and methods: In silico and in vitro approaches were implemented using NET and other cancer cell lines to predict the existence of sst5TMD4-derived peptides and test their pathological implications.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Pedraza-Arévalo S, Del Río-Moreno M, Alors-Pérez E, Castaño J, Luque R,

Keywords: sst5TMD4, derived peptides, malignancy, endocrine-related cancer,