Predictive Value of Baseline Hematology Parameters on Outcome of 177Lu-DOTATOC PRRT Abstract #1944

Introduction: In external beam radiotherapy it has been well established that improved tissue O2 increases therapy efficacy, likely mediated by O2 derived free radicals. Additionally, emerging evidence suggests immuno-stimulatory effects of radiotherapy through activation of lymphocytes.
Aim(s): In PRRT the relevance of tissue O2 and immuno-stimulation have not been evaluated to date. Therefore, we compared baseline hematology parameters with PRRT efficacy.
Materials and methods: 56 patients with metastasized, progressive and DOTATOC uptake positive NET were treated with 177Lu-DOTATOC. Patients received on average 2.1 (range 1 – 4) cycles of 7.0 GBq every 3 months. Efficacy was analyzed with RECIST 1.1. and classified as complete response, partial response, stable disease or progressive disease and correlated with baseline Hb, erythrocytes, leukocytes, lymphocytes, neutrophils and platelets. Kruskal-Wallis test was used to detect significant differences.
Conference: 14th Annual ENETS conference (2017)
Category: PRRT-Ablative therapies- Endoscopic treatment, surgical treatment
Presenting Author: Prof. Dr. Cornelis van Echteld

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Authors: Aberle S, Benz M, Grokovski R, Christ E, ...
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