Predictive Value of Baseline Hematology Parameters on Outcome of 177Lu-DOTATOC PRRT

#1944

Introduction: In external beam radiotherapy it has been well established that improved tissue O2 increases therapy efficacy, likely mediated by O2 derived free radicals. Additionally, emerging evidence suggests immuno-stimulatory effects of radiotherapy through activation of lymphocytes.

Aim(s): In PRRT the relevance of tissue O2 and immuno-stimulation have not been evaluated to date. Therefore, we compared baseline hematology parameters with PRRT efficacy.

Materials and methods: 56 patients with metastasized, progressive and DOTATOC uptake positive NET were treated with 177Lu-DOTATOC. Patients received on average 2.1 (range 1 – 4) cycles of 7.0 GBq every 3 months. Efficacy was analyzed with RECIST 1.1. and classified as complete response, partial response, stable disease or progressive disease and correlated with baseline Hb, erythrocytes, leukocytes, lymphocytes, neutrophils and platelets. Kruskal-Wallis test was used to detect significant differences.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Kluge A

Authors: Kluge A, Baum R, Kulkarni H, Niepsch K, Bitterlich N,

Keywords: PRRT, hematology, prognosis, 177Lu-DOTATOC,