Presentation and outcome of pancreaticoduodenal tumors in Multiple Endocrine Neoplasia type 1 (MEN 1) syndrome

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Introduction: Multiple endocrine neoplasia type 1 (MEN 1) is a rare autosomal dominant condition characterized by the development of parathyroid, pancreaticoduodenal endocrine and pituitaty tumors. Pancreaticduodenal endocrine tumors (PDETs) are a frequent manifestation of MEN 1, with a prevalence ranging from 30 to 75%, and represent a major cause of death in one-third of patients. There is continuing debate on their management, mainly on the optimal surgical strategy, due to their multicentricity and high recurrence rate.

Aim(s): To assess presentation and outcome of pancreaticoduodenal endocrine tumors (PDETs) in a monoinstitutional series of MEN1 patients.

Materials and methods: Prospective collected data of a cohort of MEN 1 patients observed at the internal medicine and surgical units of the University of Verona (Italy) were retrospectively analyzed.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Davi' M, Boninsegna L, Toaiari M, Scarpa A, Francia G,

Keywords: pancreaticoduodenal endocrine tumors, MEN 1,