Pretherapy Identification of Patients at Risk of Receiving a High Renal Dose Undergoing Peptide Receptor Radionuclide Therapy
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Introduction: 68GaDOTA TATE imaging of patients with neuroendocrine tumours has shown that tumour sequestration is a major factor leading to a sink effect that decreases activity concentration in healthy tissues, particularly the renal parenchyma.
Aim(s): Based on this sink effect, we propose a quantitative method for pretherapy identification of patients at risk of receiving a high renal dose while undergoing peptide receptor radionuclide therapy (PRRT).
Materials and methods: 26 patients undergoing 177LuDOTA TATE PRRT received individual dosimetry via quantitative SPECT for their first cycle of treatment. For each patient, the mean renal dose was calculated and compared to pretherapy 68GaDOTA TATE PET imaging.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author: Goodman S
Authors: Goodman S, Smith J, Ravi Kumar A, Wyld D, Burge M,
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