Prognostic Clinicopathologic Factors in Longitudinally Followed Patients with Metastatic Small Bowel Carcinoid

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Introduction: Neuroendocrine tumors demonstrate heterogeneous behavior based upon site of origin and specific histology. Even after controlling for anatomic location, disease stage and histologic grade, registry studies show persistent diversity of outcome in patients with midgut carcinoid.

Aim(s): This study aims to delineate prognostic clinicopathologic features in patients with metastatic small bowel carcinoid.

Materials and methods: A comprehensive neuroendocrine tumor database containing over 200 patients was used to identify cases of metastatic small bowel carcinoid managed at a tertiary care referral center from 1991 to 2007. All patients underwent primary tumor resection. Survival was measured from date of primary tumor resection and calculated by Kaplan-Meier estimation. When available, clinical data including age, sex, serum biomarkers, primary tumor size, Ki-67, and performance of hepatic cytoreductive procedure such as metastatectomy, ablation, or embolization were evaluated. Serially collected serum biomarkers were considered as mean values within time periods relative to primary resection: preoperative, 0-1 years postoperative and years 1 through 5 postoperative. Cox regression was applied to all variables with time dependent models used to assess prognostic value of biomarker change over time.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Curran T, Serbowicz S, Patel K, Schneiderman M, Ward S,

Keywords: carcinoid. small bowel, metastatic, chromogranin-A,