Prognostic Relevance of Pancreatic Neuroendocrine Tumors Grading on EUS-FNA

#1609

Introduction: Since WHO 2010, resected pNETs are graded as G1, G2 or G3 using the Ki67-LI. EUS-FNA is often used for diagnosis but few studies have assessed its value for grading.

Aim(s): To compare Ki67-LI obtained on cytology (cG) with histology (hG). To assess: - the influence of tumour size, and number of counted cells on FNA grading - the overall survival (OS) and progression free survival (PFS)of patients based on cG

Materials and methods: EUS-FNA was performed for 102 pNETs (57 resected), retrospectively included in this multicentre study. cG (200 cells counted) was done on all FNAs. For 29 FNAs, > 2000 cells were counted (14 resected). Comparison was made between hG and cG for the 57 resected patients. Patients were followed-up until 06/2016.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Borbath I

Authors: Boutsen L, Borbath I, Van Maanen A, Mourin A, Weynand B,

Keywords: EUS-FNA, KI67, pNET, OS,