Introduction: The accuracy of the new WHO grading system for neuroendocrine neoplasms has not yet been validated for ileal neuroendocrine tumors (iNETs).
Aim(s): To analyse the proliferation rates in primary iNETS, lymph node and distant metastases in order to determine the prognostic power of grade 1 and grade 2 categories in the WHO 2010 classification.
Materials and methods: Sixty-four primary iNETs, 35 matched node metastases and 20 distant metastases were analysed for proliferation rate (Mib1, Phospho H3/Mitosis) using automated image analysis assessing the maximum (hot spot) and overall proliferative activity. Proliferation rates were compared in different prognostic relevant cohorts (N0M0, N1M0 and N1M1).
Conference: 9th Annual ENETS Conference (2012)
Presenting Author: MD Tobias Henopp
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