Prostate-Specific Membrane Antigen (PSMA) Uptake in a Pancreatic Neuroendocrine Tumor (pNET) Bearing Patient

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Introduction: Prostate-specific membrane antigen (PSMA) is a transmembrane protein overexpressed on both prostate epithelial malignant cells and endothelial cells of tumor-associated neovasculature of many solid cancers. PSMA has been investigated already as a target in staging and detection of prostate cancer

Aim(s): Case Report

Materials and methods: A 65-year old male with multiple endocrine neoplasia syndrome (MEN-1) and an history of radically resected prostatic adenocarcinoma. Baseline 68Ga-PET/CT scan documented elevated receptor expression in the head of pancreas and multiple hepatic lesions. FNAB of liver lesion was diagnostic for pancreatic neuroendocrine tumor pNET (Ki67 5%). At diagnosis the patient began SSA treatment which was associated 2 years later with Everolimus due to hepatic progression. For a mild raise in PSA the patient underwent 67Ga-PSMA PET/CT scan which demonstrated a PSMA avid uptake in known neuroendocrine lesions (SUV max 96)

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Grego E, Antista M, Pellicciari M, Ortolani S, Cingarlini S,

Keywords: PSMA, Ga PSMA PET/CT scan, pNET,