Pure Alpha-Fetoprotein-Producing Pancreatic Neuroendocrine Tumors : A Case Report

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Introduction: Pancreatic neuroendocrine neoplasms(pNENs) with alpha-fetoprotein(AFP)-producing are extremely rare, and only one case was reported as pure AFP-producing pancreatic neuroendocrine carcinoma(pNEC) until today.

Aim(s): The present study reports the first case of pure AFP-producing pancreatic neuroendocrine tumor(pNET)(G2).

Materials and methods: A 62-year-old male patient was accepted palliative resection of the pancreatic body, tail and the most of liver metastases because of serum AFP levels was elevatory and both of pancreatic and liver mass which were enlarged by 3 cycles of long-acting-release octreotide(Sandostain LAR). Histopathologic examination determined the diagnosis of an AFP-producing pNET. The tumor were positive for chromogranin A, synaptophysin, Cluster of Differentiation 56 and AFP. The mitotic count was about 1 per 10 high-power fields and the Ki-67 index was about 10%.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Chi Y, Xu J, Shi S, Lu H, Jiang L,

Keywords: Alpha-fetoprotein, pancreatic neuroendocrine tumors,