Radio-chemotherapy versus Surgery in Non-metastatic Ano-rectal Neuroendocrine Carcinoma: A Multicenter Study by the Association des Gastro-Entérologues Oncologues

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Introduction: Neuroendocrine carcinomas (NEC) of the anus or the rectum are a rare disease, accounting for less than 1% of all digestive malignancies. Most are metastatic at diagnosis and treated with a platinum-based chemotherapy. No guidelines for localized tumors exist.

Aim(s): The purpose of this study was to describe the characteristics of ano-rectal localized NEC, their management and their outcomes.

Materials and methods: We retrospectively reviewed patients from 11 French centers with ano-rectal localized NEC. We compared two therapeutic managements: surgery (group A) versus chemotherapy with or without radiation (Group B). Progression-free survival (PFS) and overall survival (OS) were estimated with the Kaplan-Meier method.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Coriat R

Authors: Brieau B, Lepère C, Walter T, Lecomte T, Guimbaud R,

Keywords: Neuroendocrine carcinoma, ano-rectal tumor, surgery, radio-chemotherapy,