Radiological Changes in the Treatment of Pancreatic Neuroendocrine Tumors (PNET) with Sunitinib: RECIST vs CHOI Criteria. CRIPNET-GETNE Study Abstract #1932

Introduction: In PNET, phase III studies with antitarget drugs show few responses based on RECIST criteria despite a significant impact on progression free survival (PFS). Antiangiogenic drugs show in other tumors that responses are not always associated with a reduction in tumor volume on CT.
Aim(s): To explore CHOI vs RECIST criteria.
Materials and methods: CRIPNET-GETNE study include patients with advanced unresectable PNET treated with sunitinib who were evaluated by Computed Tomography (CT) using CHOI and RECIST criteria, every 3 months until progression (PD). Choi criteria sets partial response (PR) as a decrease in size of ≥10% or a decrease in tumour density (Hounfield Units, HU) ≥15% on CT. RECIST criteria sets PR as a decrease in size of ≥30% of the sum of diameters.
Conference: 14th Annual ENETS conference (2017)
Category: Imaging (radiology, nuclear medicine, endoscopy)
Presenting Author: MD Maria Pilar Solis-Hernandez
Keywords: sunitinib, PNET, choi, recist

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