Rare association between pancreatic insulinoma and Graves's disease: fortune or misfortune?

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Introduction: In spite of low frequency ( 4 cases in 1 million population), insulimoma is a significant pathology because hypoglycemia causes severe neurologic lesions and death.

Aim(s): To present a case which illustrates the impact of a rare association to Graves’s disease on the clinical signs and diagnosis of insulinoma.

Materials and methods: Sixty-one-year-old female was referred in our endocrinology department with clinical signs of hyperthyroidism. The patient was evaluated for Graves’s disease by clinical exam and laboratory tests, such as routine biochemistry, TSH, fT4 and thyroid antibody measurements. Screening tests showed a decreased glucose blood level and fasting test with insulin measurement followed. We also used ultrasound and MRI for localization study.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Fica S

Authors: Barbu C, Stefan C, Miron A, Giulea C, Calu V,

Keywords: insulinoma, Graves’s disease, hypoglicemia,