Relationship Between Dose and Molecular Response After Peptide Receptor Radionuclide Therapy (PRRNT) in Neuroendocrine Tumors: Preliminary Results Abstract #310

Introduction: PRRNT is an effective therapy option in well-differentiated neuroendocrine tumors. However, there exists no study showing the ability to predict response to PRRNT on a pretherapy Ga-68 SMS-R PET/CT.
Aim(s): To establish a dose-response relationship based upon the change in SUVmax on pre- and post-PRRNT Ga-68 SMS-R PET/CT.
Materials and methods: Ninety-six liver metastases in 67 pts treated with one cycle of PRRNT (Lu-177 DOTA-TATE) were included. Dosimetric calculations (MIRD scheme) were performed using OLINDA software. The response index (RI) was defined as: RI = (pre-therapy SUVmax – post-therapy SUVmax) / pre-therapy SUVmax.
Conference: 8th Annual ENETS Conference (2011)
Category: Clinical
Presenting Author: Prof. Dr. med. Richard P Baum
Keywords: dose, molecular, response

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