Relationship Between Dose and Molecular Response After Peptide Receptor Radionuclide Therapy (PRRNT) in Neuroendocrine Tumors: Preliminary Results

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Introduction: PRRNT is an effective therapy option in well-differentiated neuroendocrine tumors. However, there exists no study showing the ability to predict response to PRRNT on a pretherapy Ga-68 SMS-R PET/CT.

Aim(s): To establish a dose-response relationship based upon the change in SUVmax on pre- and post-PRRNT Ga-68 SMS-R PET/CT.

Materials and methods: Ninety-six liver metastases in 67 pts treated with one cycle of PRRNT (Lu-177 DOTA-TATE) were included. Dosimetric calculations (MIRD scheme) were performed using OLINDA software. The response index (RI) was defined as: RI = (pre-therapy SUVmax – post-therapy SUVmax) / pre-therapy SUVmax.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Kulkarni H, Prasad V, Schuchardt C, Baum R,

Keywords: dose, molecular, response,