Resection of Liver Metastases in Patients with High-Grade Gastroenteropancreatic Neuroendocrine Carcinomas: A Nordic Multicenter Study

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Introduction: Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are generally characterized by synchronous metastases, high aggressiveness and a dismal prognosis. Currently, resection of liver metastases in patients with metastatic GEP-NEC is not recommended. However, the existing data are scarce.

Aim(s): The aim of this study was to evaluate the role of liver surgery as part of the treatment in metastatic GEP-NEC.

Materials and methods: 32 patients with a diagnosis of GEP-NEC (Ki-67 >20%) who had intended curative resection of liver metastases, were identified among 840 patients from two Nordic GEP-NEC registries. Tumor morphology was reassessed. Overall survival (OS) and progression-free survival (PFS) was assessed by Kaplan-Meier analyses for the entire cohort and for subgroups.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Galleberg R, Knigge U, Janson E, Vestermark L, Haugvik S,

Keywords: neuroendocrine carcinoma, liver metastases, liver surgery, Ki67, survival,