Safety and Efficacy of Salvage PRRT with 177Lu-DOTA-Octreotate in Patients with Well-Differentiated Metastatic Neuroendocrine Tumours (NET) Abstract #2698

Introduction: Peptide receptor radionuclide therapy (PRRT) is an effective therapy in patients with a somatostatin receptor-positive neuroendocrine tumour (NET). NETTER-1 trial demonstrated high efficacy and low toxicity of four cycles.
Aim(s): The purpose of this study was to assess the safety of PRRT beyond the recommended 4 cycles at mean 7.4GBq in patients with metastatic NET.
Materials and methods: Between 2007-2019, we treated 205 patients with PRRT. Eleven of those (7 males, mean age 55 years) had salvage PRRT, whom we retrospectively evaluated. They had progressive WHO GI/II NET (6 small bowel, 3 pancreas, 1 lung and 1 unknown primary). All 11 patients had disease control (partial response(PR)=6, stable disease(SD)=5) following initial PRRT. The median PFS after initial PRRT was 21 months (range:11-59 months). Toxicities and additional therapies were assessed from electronic records. Biochemical and radioimaging responses were documented. Progression free survival (PFS) and Overall survival (OS) analysis was performed.
Conference: 17th Annual ENETS Conference 2020 (2020)
Category: Nuclear Medicine - Imaging and Therapy (PRRT)
Presenting Author: Nariman Ghaleb

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