Salivary-Free Catecholamines Metabolites in Pheochromocytoma

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Introduction: Salivary monitoring of hormone levels have many advantages over the more conventional serum/plasma analysis. Salivary-free metanephrines (MN) and normetanephrines (NMN) could improve biochemical diagnosis of pheochromocytoma (PHEO) as an alternative to plasma metabolites.

Aim(s): To evaluate the value of salivary catecholamine metabolites in patients with suspected pheochromocytoma, as compared with plasma catecholamine metabolites values.

Materials and methods: The prospective case-control study included a group of 30 patients confirmed with PHEO, an age-matched control group of 70 normotensive subjects. The PHEO diagnosis was suspected on clinical grounds and confirmed by imaging studies and classical neuroendocrine markers. Free plasma and salivary NMN and MN were assayed using enzyme immunoassay for both metabolites.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Stefanescu A, Schipor S, Jercalau S, Badiu C,

Keywords: pheochromocytoma, free metabolites,