Serum Chromogranin A is a Predictor for Liver Metastatic Tumor Burden and Therapeutic Response in Advanced Non-Functional Pancreatic Neuroendocrine Tumors Abstract #809

Introduction: The relationship between CgA level and liver metastatic (LM) tumor burden as well as therapeutic response is not well-established.
Aim(s): To investigate significance of CgA in the prediction of LM tumor burden and treatment response in advanced NF-PNETs.
Materials and methods: Sixty-four pts were enrolled from Dec 2011 to Sep 2013. Measurement of serum CgA was performed with ELISA Kit (CisBio) from fasted pts. The decreased/elevated CgA was defined as <50%/>50% level from baseline. We computed LM tumor burden from CT/MRI scan with less than 5mm thin slices including most amount of detectable metastases by a semiquantitative three-dimensional reconstruction approach. Change in LM tumor burden was defined as response or progression using RECIST criteria.
Conference: 11th Annual ENETS Conference (2014)
Category: Biomarkers
Presenting Author: M.D. Xu Han
Keywords: CgA NF-PNETs LM

To read results and conclusion, please login ...

Further abstracts you may be interested in

#808 Characteristics and Determinants of Long-Term Outcome for Resectable Sporadic Non-Functional Pancreatic Neuroendocrine Tumors (NF-PNETs): Updated 16-year Experience from Two Large Chinese Centers
Introduction: Non-functional pancreatic neuroendocrine tumors (NF-PNETs) are increasingly recognized with unique biology.
Conference: 11th Annual ENETS Conference (2014)
Category: Surgical treatment
Presenting Author: M.D. Xu Han
Authors: Jin G, Han X, Jin D, Hu X, ...
Keywords: NF-PNETs
#1597 The Diagnostic and Prognostic Value of Plasma CgA in Nonfunctional Pancreatic Neuroendocrine Neoplasms
Introduction: Controversies still remain on the diagnostic and prognostic value of CgA.
Conference: 14th Annual ENETS conference (2017)
Category: Biomarkers
Presenting Author: Yang Lv
Authors: Lv Y, Han X, Mao W, Zhou J, ...
#1599 The Value of Plasma CgA Combined with NSE Performed As the Real-Time Monitor of Clinical Characteristics in Gastroenteropancreatic Neuroendocrine Neoplasms after the Resection of Primary Lesions
Introduction: Controversies still remain on the clinical value of CgA and NSE.
Conference: 14th Annual ENETS conference (2017)
Category: Biomarkers
Presenting Author: Yang Lv
Authors: Lv Y, Han X, Mao W, Zhou J, ...
Keywords: cga, nse, nf-gep-nens
#1360 Development and Validation of Nomogram in Predicting Individualized Postoperative Survival for Nonfunctional Pancreatic Neuroendocrine Tumors: A Multicenter Retrospective Study
Introduction: NA
Conference: 13th Annual ENETS conference (2016)
Category: Epidemiology/Natural history/Prognosis - Prognosis
Presenting Author: Xu Han
Authors: Han X, Ma H, Feng J, Xu X, ...
#1398 Surgical Management of Nonfunctioning Pancreatic Neuroendocrine Tumors 2 cm or Less in Size: Results from a Multi-institutional Clinical Analysis in China
Introduction: There is a paucity of evidence regarding surgical management and survival in nonfunctioning PNETs 2cm or less.
Conference: 13th Annual ENETS conference (2016)
Category: Surgical treatment
Presenting Author: Meng Ji
Authors: Ji M, Jin K, Zhang Y, ...