Serum Chromogranin A is a Predictor for Liver Metastatic Tumor Burden and Therapeutic Response in Advanced Non-Functional Pancreatic Neuroendocrine Tumors

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Introduction: The relationship between CgA level and liver metastatic (LM) tumor burden as well as therapeutic response is not well-established.

Aim(s): To investigate significance of CgA in the prediction of LM tumor burden and treatment response in advanced NF-PNETs.

Materials and methods: Sixty-four pts were enrolled from Dec 2011 to Sep 2013. Measurement of serum CgA was performed with ELISA Kit (CisBio) from fasted pts. The decreased/elevated CgA was defined as <50%/>50% level from baseline. We computed LM tumor burden from CT/MRI scan with less than 5mm thin slices including most amount of detectable metastases by a semiquantitative three-dimensional reconstruction approach. Change in LM tumor burden was defined as response or progression using RECIST criteria.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Zhang C, Han X, Tang M, Ji Y, Pan B,

Keywords: CgA NF-PNETs LM ,