Single Institution Experience with Peptide Receptor Radionuclide Therapy (PRRT) in Neuroendocrine Tumors (NET)

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Introduction: Neuroendocrine tumors (NETs) are a rare and heterogenous group of tumors with rising incidence. Peptide receptor radionuclide therapy (PRRT) with radiolabeled somatostatin analogue is an encouraging systemic treatment modality with minimum side effects.

Aim(s): To present our initial experience with PRRT since FDA approval in January 2018 in patients with NET and other somatostatin receptor (SSTR) positive tumors.

Materials and methods: Sixty-one patients with progressing NETs (32 pancreas, 17 small intestine, 1 coecum, 1 gastric, 5 of unknown primary), 3 paragangliomas, and 2 pheochromocytomas underwent PRRT with 177Lu-labeled Dotatate at our institution. 68Ga-Dotatate PET/CT was performed at baseline, after 2 cycles, and following completion of treatment. RECIST and SSTR density based on change of SUVmax were used to evaluate response to therapy. Laboratory tests were obtained at baseline and 1 week before each cycle and every 2 months at follow up. Progression-free survival (PFS), objective response rate (ORR) and toxicity were assessed. Considering the short follow-up time, an interim overall survival (OS) analysis was performed.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Duan H

Authors: Duan H, Ninatti G, Girod B, Ferri V, Guja K,

Keywords: NET, PRRT, ORR, PFS,