Z-Archiv 6th Annual ENETS Conference, Granada, Spain

6th Annual ENETS Conference draws record number of participants to Granada, Spain

The 6th Annual ENETS Conference, held in early March, drew approximately 1,100 participants, the highest number of attendees yet for the yearly meeting. Sponsored by Novartis and Ipsen, both of which held satellite symposia during the conference, the event attracted about 120 abstracts submissions. The abstracts are slated to be published in Neuroendocrinology as a supplement this summer.

The complete conference program can be viewed via the ENETS website. Some highlights include:

An introductory session presented ENETS Standards of Care. Chaired by Ashley Grossman, and Ursula Plöckinger, the diagnosis of neuroendocrine tumors, medical therapy and surgical therapy were reviewed and the consensus of required standards for appropriate patient care were explained by presenters Barbro Eriksson, Philippe Ruszniewski and Goran Åkerström, respectively.


An intense clinical abstracts session, chaired by Gregory Kaltsas and Hironobu Sasano followed, during which five noteworthy abstracts from the annual conference were presented by Joy Ardill, Aurora Astudillo, Rosella Bettini, Phil Brown, and Alberto Falchetti. Drs. Bettini and Strosberg were both awarded monetary prizes for their clinical research work, as were Pavel Szybinski and Vikas Prasad, both of whom presented their abstracts in poster format.


The second day of the conference saw a clinical session addressing “various locations, various problems” with Wouter de Herder and Gianfranco Delle Fave chairing. Eric Baudin presented on neuroendocrine tumors of the lung; Bertram Wiedenmann on pancreatic NET; and John Ramage on rectal NET. Their cases raised pointed questions and the presenters’ responses were well-taken.


After this, the ENETS Life Achievement award was presented to Rudolf Arnold by Bertram Wiedenmann. Prof. Arnold, who worked and taught at the university hospital in Marburg and who currently lives in Munich, received the prize in recognition of his notable career in NET research and treatment. Having been taught by Werner Creutzfeldt – the 2005 ENETS Life Achievement Award recipient - he continued working in basic and seminal clinical research, defining the clinical diagnosis, clinical course and treatment modalities of NET. He particularly investigated biotherapeutic treatment strategies, heading trailblazing clinical trials, including his most recent, which is the only placebo-controlled randomized clinical trial with octreotide in midgut NET (PROMID).

The morning continued with a session dedicated to poorly differentiated endocrine carcinomas, chaired by Larry Kvols and Paul Komminoth. Ola Nilsson presented an overview on diagnosis, outlining histopathological characteristics of these highly malignant neuroendocrine neoplasms. Håkan Ahlman outlined the principles of surgical approaches to these patients while James Yao presented medical strategies for treating patients.

Further novel developments in clinical research were later discussed in a second clinical abstracts session chaired by Martyn Caplin and Diego Ferone. Piero Ferolla, Leszek Krolicki, Tim Meyer, Anja Rinke, and Jonathan Strosberg presented interesting developments mostly on treatment of neuroendocrine tumors with high relevance to daily routine. The day was closed with a session, chaired by Reza Kianmanesh and Barbro Eriksson, on dealing with established techniques and novel approaches of surgery in neuroendocrine tumors. Organized by primary tumors, Eric Lim presented results in lung NET, Irvin Modlin discussed intestinal NET and Alain Sauvanet reported on pancreatic NET.


The final day of the conference offered a session on liver metastases chaired by Dermot O’Toole and Dik Kwekkeboom. Danny Welch gave an impressive overview on key players in metastases development. Thomas Steinmüller thoroughly presented the data on surgical and ablative treatment options, while Kjell Öberg gave an overview of medical treatment of NET metastatic to the liver.


The following abstract session, chaired by Raj Thakker and Ulrich Frank Pape, presented the most noteworthy basic and translational research abstracts of this year’s conference. Anne Couvelard, Atul Kalhan and Mei Mei presented new aspects of basic and translational research which will hopefully have some impact on understanding and managing NET disease. Drs. Kalhan and Mei were awarded monetary prizes for their efforts in the basic/translational sciences.


The final session, chaired by Beata Kos-Kudła and Matthew Kulke highlighted combined therapies and current clinical trails, thereby summarizing some of the most interesting messages of this year’s ENETS Annual Conference. Catherine Lombard-Bohas and James Yao summarized the results of “hot-off-the-press results of clinical trials” in the European Union and USA, respectively. Larry Kvols discussed the need for new combinations of the substances tested in recent monotherapy trials, be it combinations with standard or new drug regimens or treatment modalities such as PRRT. Eric Van Cutsem gave an inspiring lecture titled “Basic evidence for future trials,” explaining his perspective on the principles of how therapy development and testing in clinical trials should be handled. The scientific program was closed by a summary lecture given by Robert Jensen, who presented the lessons from Granada all participants might take home.