Introduction: mRNA signatures of distinct metastatic phenotypes of pancreatic NETs (pNETs) exhibit differences in several components of the Slit-Robo axon guidance system.
Aim(s): We aimed at delineating the role of Slit-Robo signaling for tumor progression in pNETs.
Materials and methods: Expression of Slit2 and Robo1 on human pNET tissues was determined by IHC and qPCR. Migration and colony formation as well as metastasis in mice were evaluated as read-outs.
Conference: 13th Annual ENETS conference 2016 (2016)
Category: Basic Science - mTOR and other pathways, signalling, receptors
Presenting Author: PD Dr. med. Christian Fischer
, Göhrig A
, Hilfenhaus G
, Körner J L
, Lombardi M
, Welzel M
, Behm A
, Arsenic R
, Grötzinger C
, Pascher A
, Wiedenmann B
, Fischer C
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