Slit2-Robo1 Signaling Activates Ras to Suppress Metastasis and Is Associated with Time-To-Progression in Pancreatic Neuroendocrine Tumors

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Introduction: Transcriptom analysis revealed that mRNA signatures of distinct metastatic phenotypes in pancreatic NETs (pNETs) exhibit differences in components of the Slit-Robo pathway.

Aim(s): Delineating the role of Slit2 and its receptor Robo1 for pNET progression.

Materials and methods: Expression analysis in human pNETs was determined by IHC and qPCR. Migration, colony formation, and metastasis of mouse orthotopic pNETs were evaluated using pNET cells with restored Slit2 expression or Robo1 inactivation.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Fischer C, Göhrig A, Körner J, Lombardi M, Welzel M,

Keywords: NET, ras, slit, robo, metastasis, orthotopic,