Somatostatin receptors 1-5 expression in a large series of well-differentiated neuroendocrine tumors Abstract #120

Introduction: For their antisecretive and antiproliferative effect somatostatin analogs (SA) have been used in the treatment of neuroendocrine tumors (NETs), based on the expression of somatostatin receptors (sstRs). The potential availability of new SA for the treatment of patients with NETs suggests a better characterization of sstRs.
Aim(s): To evaluate by immumohistochemistry (IHC) the presence of sstRs 1-5 in a series of well-differentiated (WD) NETs and to relate sstRs expression to clinical-pathological data.
Materials and methods: Forty-six WD-NET samples (14 bronchial, 15 pancreatic, two duodenal gastrinomas, three gastric, five ileal/ileocecal valve-NETs, one rectal, three appendiceal, one paraganglioma, one liver and one node metastasis) were studied. IHC was performed using sstR 1-5 antibodies (Santa Cruz-California). Specimens with <10% positive cells were considered negative.
Conference: 7th Annual ENETS Conference (2010)
Category: Basic
Presenting Author: Dr Paola Loli

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