Somatostatin Receptors Profile in Pulmonary NETs Associated with DIPNECH

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Introduction: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare entity characterised histologically by the proliferation of neuroendocrine cells along the distal bronchiolar epithelium, associated with small tumourlets and usually found in association with pulmonary carcinoid tumour. This can be clinically silent or may be associated with symptomatic obstructive bronchiolitis.

Aim(s): To study the pattern of expression of the somatostatin receptors 1-5 is in pulmonary NETs associated with DIPNECH by immunohistochemistry.

Materials and methods: We retrospectively reviewed histologically proven DIPNECH (recent definition by Marchevsky AM, 2015), and examined the pattern of expression of the five SSTRs by immunohistochemistry on archival paraffin-embedded tissue.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Fabre A

Authors: Ryan C, Fabre A, Di Capua D, Swan N, Power D,

Keywords: SSTR, DIPNECH, carcinoid,