SOMscan: Towards a Ga-68-labeled Pan-Somatostatin PET Imaging Probe Based on SOM230 (Pasireotide) Abstract #447

Introduction: The somatostatin receptor subtype sst2 is largely expressed on neuroendocrine tumors. However, current clinical studies indicate that the subtypes sst1, 3, 5 are of substantial relevance as well.
Aim(s): We intend to develop a Ga-68-PET tracer covering a broad spectrum of ssts for clinical application.
Materials and methods: The sst1, 2, 3, 5 highly specific SOM230 (Pasireotide) was coupled with the chelators DOTA or NODAGA and labeled with Ga-68. We investigated the tracers’ sst-subtype binding and internalization profiles in vitro and the biodistribution and tumor uptake by microPET studies in hsst2- and hsst5-tumor xenografts.
Conference: 9th Annual ENETS Conference (2012)
Category: Basic
Presenting Author: Dr. Melpomeni Fani
Keywords: SOM230, Ga-68, PET imaging

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