Structure of complications in acromegalic patients at a single institute Abstract #86

Introduction: Acromegaly leads to reduced life expectancy, with an increase in the mortality rate. From several retrospective cohort studies, the predominant outcome is serum growth hormone (GH) concentration. Other factors associated with increased mortality include duration of symptoms prior to diagnosis, duration of disease, older age at diagnosis and the presence of cardiovascular disease, diabetes mellitus (DM) and hypertension at diagnosis.
Aim(s): To study the structure of complications in active acromegaly from data from V. Danilevsky Institute for endocrine pathology AMS in the Ukraine.
Materials and methods: Between 2006 and 2009, 39 patients (13 men and 26 women; aged 18–76 years, mean age (50.79±11.33) years; four of them with acromegalia de novo one one with McCune-Albright syndrome) were treated in whom active acromegaly (according to their clinical profile: high GH concentrations not suppressible by oral glucose tolerance test (OGTT) load to less than 1 ng/ml) during a month of disease (191.68±109.11) month. All patients had macroadenoma of hypophysis (27 - somatotropinoma and 12 - somatomammotropinoma) including four patients with relapse of adenoma. Twenty patients had been previously treated by neurosurgery (85% transsphenoidal adenomectomia) and three of them had been irradiated 1-6 years before the study began. Blood samples for GH measurements were taken in fasting state and after OGTT.
Conference: 7th Annual ENETS Conference (2010)
Category: Clinical
Presenting Author: OKH OKSANA OLEGOVNA KHYZHNYAK

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