Study of the Biological Significance of the IGF-IEc (MGF) in Well and Poorly Differentiated Neuroendocrine Neoplasms

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Introduction: Insulin-like growth factor-I (IGF-I) has a key role in cell proliferation, differentiation, migration, and survival. Different IGF-I mRNA transcripts, such as IGF-IEc (mechano growth factor, MGF), are produced by alternative splicing. MGF has been implicated in muscle regeneration process as well as in the pathophysiology of various types of cancer.

Aim(s): The role of MGF in the pathophysiology of neuroendocrine neoplasms (NENs).

Materials and methods: We have used an anti-MGF specific antibody to examine by immunohistochemistry the expression status (rate, %) of MGF in 39 specimens of patients with NENs [8 gastric, 11 pancreatic, 2 appendiceals, 7 small intestine, 1 colic and 1 retrosigmoidal, 1 gallblader and 3 lung NENs, 2 undifferentiated unknown primary (UPO), 3 UPO]. Proliferation index ki-67 MIBI (%) was also evaluated.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Alexandraki K

Authors: Alexandraki K, Philippou A, Boutzios G, Theohari I, Moschouris P,

Keywords: Neuroendocrine neoplasms, MGF, IGF-IEc, ki-67,