Subtype Classification and Clinicopathological Features of Gastric Neuroendocrine Neoplasms: 400 Cases of Multicenter Retrospective Analysis Abstract #2125

Introduction: Definitions of Type 3 gastric NEN (g-NEN) in ENETS Guidelines 2012 and 2016 are ambiguous and controversial, so Four-type classification has been proposed in China.
Aim(s): To explore the clinicopathological features and prognosis of g-NENs using modified type classification.
Materials and methods: A total of 400 cases with g-NENs were collected from five hospitals in China, including China-Japan Friendship Hospital, The First Affiliated Hospital of Sun Yat-Sen University, etc, Jan 2011-Nov 2017. According to serum gastrin, 24-hour intragastric pH monitoring and pathological grading, petients with g-NENs were divided into four distinct types: type 1 (hypergastrinemia and achlorhydria, related to autoimmune chronic atrophic gastritis), type 2 (hypergastrinemia and ZES, related to gastrinoma or MEN-1, type 3 (sporadic disease with normal serum gastrin level). Poorly differentiated g-NEN (NEC,MANEC) are type 4. The clinicopathological features, management and prognosis of all types were analyzed.
Conference: 15th Annual ENETS conference (2018)
Category: Epidemiology/Natural history/Prognosis- Registries, nationwide and regional surveys
Presenting Author: Prof. Huang-Ying Tan

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