Subtype Classification and Clinicopathological Features of Gastric Neuroendocrine Neoplasms: An Analysis of 241 Cases

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Introduction: Definition of type 3 gastric NEN in 2012 and 2016 ENETS guidelines is not clear, so Four-type classification has been proposed.

Aim(s): To explore classifications of gastric NEN in Chinese population.

Materials and methods: A total number of 241 gastric NEN cases were collected, using data from China-Japan Friendship Hospital and The First Affiliated Hospital of Sun Yat-Sen University, Jan 2011-Jun 2016. According to serum gastrin, 24-hour intragastric pH monitoring and pathological grading, pts with gastric NEN were subdivided into 4 types: type 1 (hypergastrinemia and achlorhydria, related to autoimmune chronic atrophic gastritis), type 2 (hypergastrinemia and ZES, related to gastrinoma or MEN-1, type 3 (sporadic disease with normal serum gastrin level). Poorly differentiated gastric NEC and MANEC belong to type 4. The clinicopathological features, treatment and prognosis of all types were summarized.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Tan H

Authors: Tan H, Dou D, Zhang P, Zhang C, Zhang Y,

Keywords: gastric nen, subtype,