Succinate Dehydrogenase (SDHB): A New Marker of Malignancy in Midgut Carcinoids? Abstract #473

Introduction: The immunoistochemical (IHC) loss of SDHB expression was reported as a surrogate marker of malignancy in sporadic and familial pheocromocytomas/paragangliomas. SDHB loss is supposed to be tumorigenic (activation hypoxia signals).
Aim(s): SDHB levels evaluation in advanced midgut carcinoids and its potential role as a prognostic marker.
Materials and methods: Thirty-one midgut carcinoids were identified: 78% males, 22% females, median age 55.5 yrs (range 19-75). All pts were NET G1, stage IV synchronous liver metastases. 25/31 underwent surgical primary resection. 70% were up front treated with somatostatin analogues. SDHB and MIB1 expression were carried out in 19 primary tumors (T) and in 19 liver metastasis (M). In eleven pts, SDHB and MIB1 were tested both in T and in M. SDHB was evaluated with a semiquantitative scale considering staining intensity score 1 (low), 2 (high).
Conference: 9th Annual ENETS Conference (2012)
Category: Basic
Presenting Author: MD Sara Pusceddu
Keywords: SDHB

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