Targeting Chaperone Activity and Chaperone Expression in Human GEP-NET Cells Can Repress Their Proliferation and Sensitize Them to Chemotherapy

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Introduction: New approaches for better treatment of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are acutely needed. Inhibitors of chaperone activity of heat shock protein 90 (Hsp90) seem to be promising agents but they upregulate cytoprotective chaperones Hsp70 and Hsp27.

Aim(s): We examined effects of simultaneous inhibition of both the Hsp90 chaperone activity and induction of Hsp70 and Hsp27 on the GEP-NET cell sensitivity to conventional chemotherapy.

Materials and methods: Human pancreatic carcinoid (BON) and insulinoma (CM) cell lines were subjected to 17AAG and inhibitors of the Hsp induction (quercetin, triptolide, NZ28) and conventional drugs (oxaliplatin, doxorubicin, etoposide).

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Demidkina A, Kudryavtsev V, Mosina V, Kabakov A,

Keywords: chemosensitization, heat shock protein, 17AAG,