TGF-β increase caspase activation and migration in typical bronchial carcinoids Abstract #3320

Introduction: Typical bronchial carcinoids (TBC) are well-differentiated neuroendocrine neoplasms (NEN) whose management can still be very challenging due to reduced sensitivity to therapy. Previous studies have reported TGF-β’s ability to activate mTOR pathway and induce epithelial to mesenchymal transition (EMT). Moreover, preliminary results show an overexpression of TGF-β signalling and caspase activation in TBC.
Aim(s): In order to understand the possible role for TGF-β signalling in TBC, and its crosstalk with mTOR, functional assays (cell viability, migration and caspase 3/7 activation) were performed in vitro in TBC cells.
Materials and methods: Cells were treated with the mTOR inhibitor everolimus (eve) and TGF-β alone or combined with controls IGF-1 and paclitaxel (pac).
Conference: 18th Annual ENETS Conference 2021 (2021)
Category: Basic science - Signalling pathways, receptors, biomarkers
Presenting Author: Patricia Borges de Souza

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