The Grading of pNENs in MEN-1 Syndrome: Consequences for Tumor Progression and Surgical Strategy? Abstract #774

Introduction: MEN-1 patients develop multiple pNENs. The treatment of choice ranges from watchful waiting to total pancreatectomy. Up to now, the impact of the grading has not been evaluated to either plan surgery or conservative treatment.
Aim(s): To determine the relevance of the grading (WHO 2010) compared to size (WHO 2000) for the decision for surgery or conservative treatment in MEN-1 patients with pancreatic neuroendocrine neoplasms (pNENs).
Materials and methods: Three patients with MEN-1-associated multiple pNENs underwent total pancreatectomy. The specimens were retrospectively analyzed and the tumors were immunohistochemically restained. The grading according to the Ki-67 index was compared to size.
Conference: 10th Annual ENETS Conference (2013)
Category: Non digestive NETs (bronchial, MTC, pheochromocytoma)
Presenting Author: Dr. Andreas Selberherr
Keywords: MEN-1, pancreas, pNEN

To read results and conclusion, please login ...

Further abstracts you may be interested in

#762 Long-Term Follow-Up of MEN-1 Patients with Non-Operated Small < 2 cm Non-Functional Neuroendocrine Tumor of the Pancreas (NF-PET)
Introduction: Previous investigations from the GTE demonstrated that the risk to develop metastasis and/or death was very small for MEN-1 patients with NF-PET < 2 cm. However, the follow-up was only 3.3 years for the non-operated patients.
Conference: 10th Annual ENETS Conference (2013)
Category: Surgical treatment
Presenting Author: MD Frederic Triponez
Keywords: MEN-1, NF-PET
#442 Low Diagnostic Accuracy of Tumor Markers for the Annual Screening of Pancreatic Neuroendocrine Tumors in MEN-1 Patients
Introduction: The use of tumor markers for annual screening for pancreatic neuroendocrine tumors (pNET) in Multiple Endocrine Neoplasia type 1 (MEN-1) is debatable because of low-level evidence and high costs.
Conference: 9th Annual ENETS Conference (2012)
Category: Clinical
Presenting Author: MD PhD Gerlof Valk
#2033 Ki-67 and Presence of Liver Metastases Predicts Progression in Pancreatic Neuroendocrine Neoplasms (pNENs)
Introduction: In pancreatic neuroendocrine neoplasms (pNENs), size ≤20 mm and Ki-67 ≤2% suggest indolent behavior, but no factor alone can predict prognosis.
Conference: 15th Annual ENETS conference (2018)
Category: Pathology - grading, staging
Presenting Author: MD, PhD Massimo Milione
#524 Sunitinib in a MEN-1 Patient with Small Cell Neuroendocrine Tumor of the Thymus
Introduction: MEN-1 is an autosomal dominant disease caused by mutation of the oncosuppressor gene menin. MEN-1 is typically associated with hyperparathyroidism, islet cell tumors and pituitary adenomas, but it can also be associated with other neoplasms, such as thymic carcinoids.
Conference: 9th Annual ENETS Conference (2012)
Category: Basic
Presenting Author: Prof Giovannella Palmieri
#673 MEN-1: Difficulties in Diagnosis and Therapeutic Dilemmas
Introduction: MEN1 is rare, and the most common mode of presentation is in previously identified kindred, but may be the propositus of a new kindred or a sporadic case.
Conference: 10th Annual ENETS Conference (2013)
Category: Basic Science - mTOR and other pathways, signalling, receptors
Presenting Author: Joana Saraiva
Authors: Saraiva J, Santos J, Moreno C, Alves M, ...