The Grading of pNENs in MEN-1 Syndrome: Consequences for Tumor Progression and Surgical Strategy?

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Introduction: MEN-1 patients develop multiple pNENs. The treatment of choice ranges from watchful waiting to total pancreatectomy. Up to now, the impact of the grading has not been evaluated to either plan surgery or conservative treatment.

Aim(s): To determine the relevance of the grading (WHO 2010) compared to size (WHO 2000) for the decision for surgery or conservative treatment in MEN-1 patients with pancreatic neuroendocrine neoplasms (pNENs).

Materials and methods: Three patients with MEN-1-associated multiple pNENs underwent total pancreatectomy. The specimens were retrospectively analyzed and the tumors were immunohistochemically restained. The grading according to the Ki-67 index was compared to size.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Selberherr A

Authors: Selberherr A, Koperek O, Niederle B,

Keywords: MEN-1, pancreas, pNEN,