The importance of endoscopic ultrasound in detecting recurrent gastrinoma in a case of MEN 1 Abstract #135

Introduction: Approximately 25-30% of patients have gastrinomas as part of the inherited syndrome Multiple Endocrine Neoplasia 1 (MEN 1). Gastrinomas occur in the pancreas, duodenum or peripancreatic lymph nodes. Diagnosis is made by clinical history, gastroscopy, and measurement of serum gastrin, gastric juice pH, CT scan, endoscopic ultrasound (EUS) and somatostatin receptor scintigraphy (SRS). Localization of gastrinomas in patients with MEN 1 is challenging due to their small size, frequent duodenal location, and multiplicity.
Aim(s): To report the diagnostic difficulties and role of EUS in a clinical case of recurrent gastrinoma in MEN 1.
Materials and methods: EUS with FNA biopsy was carried out by an experienced endoscopic team at the digestive endoscopic unit of our hospital.
Conference: 7th Annual ENETS Conference (2010)
Category: Clinical
Presenting Author: Prof. Laura De Marinis

To read results and conclusion, please login ...

Further abstracts you may be interested in

#91 Endoscopic ultrasound of 66 insulinomas
Introduction: Ultrasound is the virtual representation of the morphology of organs and tissues. Endoscopic ultrasound can be used in detailed scanning of pancreas and preoperative topical diagnostics of insulinomas. Insulinoma requires surgical treatment in all cases. This fact allows control of preoperative diagnostic methods.
Conference: 7th Annual ENETS Conference (2010)
Category: Clinical
Presenting Author: MD Tatiana L. Silina
#543 Endoscopic Ultrasound-Guided Fine Needle Tissue Acquisition (EUS-FNTA) Using a 19-G Needle for Histological Grading of Pancreatic Endocrine Tumors (PETs): A Prospective Study
Introduction: EUS-FNTA is increasingly used in the diagnosis of pancreatic endocrine tumors (PETs). Ki-67 expression, an important prognostic factor according to the WHO classification, is difficult to be determined on cytological specimens.
Conference: 9th Annual ENETS Conference (2012)
Category: Clinical
Presenting Author: Prof Laura De Marinis
Authors: Larghi A, Fusco A, Bianchi A, Lugli F, ...
Keywords: EUS, Ki-67, grading, pancreas
#1012 Efficacy of Lanreotide Autogel in MEN1-Related Gastrinoma: A Case Series
Introduction: GEP NETs, especially gastrinomas, occur in 40-70% of MEN1 patients and represent the main cause of death in these patients.
Conference: 11th Annual ENETS Conference (2014)
Category: Medical treatment - SMS analogues, interferon
Presenting Author: Laura De Marinis
Keywords: MEN1, SSA, gastrin
#126 Assessment of the proliferation marker Ki-67 by endoscopic ultrasound guided-Fine Needle Aspiration (EUS-FNA) in pancreatic endocrine tumors: A comparative analysis with histology of the surgical specimen
Introduction: Assessment of the proliferative index by Ki-67 immuno-labelling is an important prognostic parameter for the biologic behavior of digestive neuroendocrine tumors, usually established on the histological specimen obtained after surgery or macro-biopsy. However, small pancreatic endocrine tumors (PET) are more and more often recognized by CT/MRI and diagnosed by EUS. The value of Ki-67 labelling index (Ki-67-LI) on fine needle aspiration (FNA) is not well-established in this setting, although regularly assessed.
Conference: 7th Annual ENETS Conference (2010)
Category: Clinical
Presenting Author: Dr Ivan Borbath
#142 The role of 18F DOPA-PET in a case of malignant pheochromcytoma
Introduction: Pheocromocytoma is a rare tumor arising from chromaffin cells of adrenal medullary or extra adrenal paraganglionic tissue. Histological criteria cannot differentiate benign from malignant pheocromocytomas. The diagnosis of a malignant pheocromocytoma requires local invasion, recurrence and documented metastatic disease. The radionuclide scanning (123I - 131I-MIBG) is a fundamental diagnostic tool used to confirm the biochemical and radiological diagnosis of pheochromocytoma. In fact, MIBG scanning may confirm that the visualised lesion in an adrenal gland is indeed a pheochromocytoma and detect extra-adrenal paraganglionic tissue. However, MIBG scans are negative in around 15% of benign pheochromocytomas and in up to 50% of malignant ones. Other radionuclide techniques (18FDG-PET, 18F-DOPA-PET, 18F-FDA-PET) have been successfully used in investigation of pheochromocytomas. 18F-DOPA-PET and 18F-FDA-PET have been reported to be highly sensitive and specific for benign pheochromocytomas, while 18FDG-PET can be useful for malignant lesions with higher metabolic activity.
Conference: 7th Annual ENETS Conference (2010)
Category: Clinical
Presenting Author: Prof. Laura De Marinis