The importance of endoscopic ultrasound in detecting recurrent gastrinoma in a case of MEN 1

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Introduction: Approximately 25-30% of patients have gastrinomas as part of the inherited syndrome Multiple Endocrine Neoplasia 1 (MEN 1). Gastrinomas occur in the pancreas, duodenum or peripancreatic lymph nodes. Diagnosis is made by clinical history, gastroscopy, and measurement of serum gastrin, gastric juice pH, CT scan, endoscopic ultrasound (EUS) and somatostatin receptor scintigraphy (SRS). Localization of gastrinomas in patients with MEN 1 is challenging due to their small size, frequent duodenal location, and multiplicity.

Aim(s): To report the diagnostic difficulties and role of EUS in a clinical case of recurrent gastrinoma in MEN 1.

Materials and methods: EUS with FNA biopsy was carried out by an experienced endoscopic team at the digestive endoscopic unit of our hospital.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: De Marinis L

Authors: Fusco A, Lugli F, Bianchi A, Iacovazzo D, Larghi A,

Keywords: endoscopic ultrasound, gastrinoma, MEN 1 ,