The Positive Expression of PD-L1/PD-1 in Gastroenteropancreatic Neuroendocrine Neoplasias Correlates with Prognosis

#1630

Introduction: The incidence of Neuroendocrine Neoplasias (NENs) is increasing and their pathological characteristics, varied between races. However, the epidemiology of GEP-NENs in Chinese patients remains poorly characterized especially for the expression of important immune checkpoint protein PD1 and PD-L1.

Aim(s): This study aims to examine the pathological/clinical characteristics, detect the expression of programmed cell death ligand 1 (PD-L1) / programmed cell death protein 1 (PD-1) in the tissue from patients with GEP-NENs, and analyze the correlation with prognosis furtherly.

Materials and methods: Immunohistochemistry staining of PD-1 and PD-L1 was performed in 120 GEP-NENs tissue specimens. Other clinical, pathological data were collected as well. The correlation between PD-1/PD-L1 expression and the prognosis of patients were analyzed furtherly.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Yinying W, Chuying W,

Keywords: gastroenteropancreatic neuroendocrine neoplasias, PD-L1, PD-1, immunohistochemistry, prognosis,