The role of Ki-67 in the prognosis and management of neuroendocrine (NET) patients in a multdisciplinary cancer center

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Introduction: The role of Ki-67 in NETs has become increasingly important, especially in light of the current trend in oncology to incorporate pathological molecular characteristics in determining treatment. In North America, Ki-67 is used inconsistently, as there exists some debate in the literature about its predictive value.

Aim(s): To re-examine a series of NETs patients to determine the role of Ki-67 on both clinical presentation and outcomes.

Materials and methods: A retrospective chart review with a supplemental pathology review was instituted for all patients undergoing multidisciplinary management for NETs between 2001 to 2008. Clinical, laboratory and outcomes data were collected into a integrated database, with supplemental pathology review for data missing on the original pathology reports. Ki-67 was measured. Ki-67 was then categorized into three categories 15%(C). Due to sample size limitations, we compared treatment and outcome data using a stratified analysis of ≥5% and >5%.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Singh S

Authors: Singh S, Rowsel C, Ingber N, Yang S, Law C,

Keywords: neuroendocrine, Ki-67, predictive marker,