The Role of p27 in Pheochromocytoma Development

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Introduction: The Cdkn1b gene, encoding p27, is a tumor susceptibility gene for multiple endocrine neoplasia syndromes in rats (MENX) and humans (MEN4) with development of pheochromocytoma (PCC), respectively. Recently, it was reported that p27 indirectly regulates gene transcription by associating with transcription factors (TF) and inhibiting gene transcription at specific promoters.

Aim(s): We hypothesized that defective p27 may promote tumor formation in adrenomedullary cells because of aberrant gene expression regulation.

Materials and methods: We used adrenomedullary tissue from WT rats (with normal p27 levels) or normal adrenomedullary cells of human individuals and performed chromatin immunoprecipitation-sequencing (ChIP-Seq).

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Richter A

Authors: Richter A, Lalli E, Sass S, Pellegata N,

Keywords: pheochromocytoma, p27, ChIP-Seq,