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The use of F-18-FDG-PET for patients with neuroendocrine tumors

#138

Introduction: Neoplastic tissue exhibits high glucose utilization, which can be imaged by 18F-Fluorodeoxyglucose-positron emission tomography (FDG-PET). Whether FDG-PET is useful for neuroendocrine (NE) tumors, however, is questionable, due to the slow growth rate often observed in these tumors.

Aim(s): To investigate the diagnostic and prognostic value of FDG-PET and to compare this with the cellular proliferation index in these often slow-growing tumors.

Materials and methods: Ninety-eight prospectively enrolled patients with NE tumors underwent FDG-PET imaging. The prognostic value of FDG uptake and proliferation index, as determined by immunohistochemical staining for Ki-67 was evaluated. In addition, the diagnostic sensitivity of FDG-PET was assessed and the imaging results were compared with the proliferation index.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Binderup T

Authors: Binderup T, Knigge U, Pfeifer A, Federspiel B, Palnæs Hansen C,

Keywords: neuroendocrine tumors, F-18-FDG-PET, proliferation index,

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