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The Utility of Alpha Internexin as a Predictive Tissue Biomarker for Proliferation in Gastrointestinal and Pancreatic Neuroendocrine Tumors

#309

Introduction: GEP-NETs are increasing but Ki-67 and CgA provide limited information regarding malignancy. A key unmet need is alternative biomarkers to assess the likelihood of local invasion or metastasis.

Aim(s): To assess the utility of alpha-internexin (INA), an axonal intermediate filament protein identified in insulinomas, as a GEP-NET biomarker of malignancy.

Materials and methods: We assessed INA transcript levels in 50 pancreatic NETs (pNETs: 43 local, seven mets), 43 small intestine NETs (25 local, 18 mets), normal pancreas (12), normal SI mucosa (16), normal EC cells (n=9) and GEP-NET cell lines (n=7) using real-time PCR. Statistical analyses included 2-tailed Mann-Whitney-Tests and Spearman correlations.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Schimmack S, Lawrence B, Svejda B, Fischer L, Schmitz-Winnenthal H,

Keywords: alpha-internexin, biomarker, GEP-NET, INA, Ki-67, malignancy, metastasis, neuroendocrine tumor, PCR,

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