The Utility of Alpha Internexin as a Predictive Tissue Biomarker for Proliferation in Gastrointestinal and Pancreatic Neuroendocrine Tumors Abstract #309

Introduction: GEP-NETs are increasing but Ki-67 and CgA provide limited information regarding malignancy. A key unmet need is alternative biomarkers to assess the likelihood of local invasion or metastasis.
Aim(s): To assess the utility of alpha-internexin (INA), an axonal intermediate filament protein identified in insulinomas, as a GEP-NET biomarker of malignancy.
Materials and methods: We assessed INA transcript levels in 50 pancreatic NETs (pNETs: 43 local, seven mets), 43 small intestine NETs (25 local, 18 mets), normal pancreas (12), normal SI mucosa (16), normal EC cells (n=9) and GEP-NET cell lines (n=7) using real-time PCR. Statistical analyses included 2-tailed Mann-Whitney-Tests and Spearman correlations.
Conference: 8th Annual ENETS Conference (2011)
Category: Basic
Presenting Author: Dr Mark Kidd

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