Tissue Prognostic Markers in Pancreatic Neuroendocrine Tumours Abstract #1273

Introduction: Pancreatic neuroendocrine tumours (pNETs) are a rare, heterogeneous class of neoplasms, with a rising incidence. Prognosis is variable with 5-year survival as low as 16% in inoperable tumours.
Aim(s): The role of the microenvironment in influencing prognosis is poorly described is the focus of this research.
Materials and methods: A thorough literature review has performed to identify important aspects of pNET microenvironments. A database of 131 patients with pNETs has been generated including all clinical, histopathological and survival data. Tissue Microarrays (TMAs) have been produced from paraffin-embedded primary and metastatic tumour tissue. These have been immunohistochemically stained for immune, stromal, signalling and vascular markers to identify prognostic markers.
Conference: 13th Annual ENETS conference (2016)
Category: Pathology, grading, staging
Presenting Author: Dr Jonathan Dunbar

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