Tissue Prognostic Markers in Pancreatic Neuroendocrine Tumours

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Introduction: Pancreatic neuroendocrine tumours (pNETs) are a rare, heterogeneous class of neoplasms, with a rising incidence. Prognosis is variable with 5-year survival as low as 16% in inoperable tumours.

Aim(s): The role of the microenvironment in influencing prognosis is poorly described is the focus of this research.

Materials and methods: A thorough literature review has performed to identify important aspects of pNET microenvironments. A database of 131 patients with pNETs has been generated including all clinical, histopathological and survival data. Tissue Microarrays (TMAs) have been produced from paraffin-embedded primary and metastatic tumour tissue. These have been immunohistochemically stained for immune, stromal, signalling and vascular markers to identify prognostic markers.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Dunbar J

Authors: Dunbar J, Tod J, Horne J, Armstrong T, Cave J,

Keywords: Pancreatic, microenvironment, prognosis,