Triple Tracer Imaging Approach for the Non-Invasive Assessment of Chemokine Receptor 4 Expression in Gastroenteropancreatic Neuroendocrine Tumors

#1596

Introduction: The theranostic twins [68Ga]Pentixafor and [177Lu]Pentixather for chemokine-directed endoradiotherapy (ERT) were recently developed.

Aim(s): We aimed to evaluate feasibility of non-invasive CXCR4 PET/CT imaging using [68Ga]Pentixafor in comparison to 68Ga-DOTA-D-Phe-Tyr3-octreotide ([68Ga]DOTATOC) and 18F-fluorodeoxyglucose ([18F]FDG).

Materials and methods: 12 patients with histologically proven GEP-NET underwent [68Ga]DOTATOC, [18F]FDG and [68Ga]Pentixafor PET/CT. Scans were analyzed on a patient as well as on a lesion basis.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Werner R

Authors: Werner R, Weich A, Higuchi T, Schmid J, Schirbel A,

Keywords: Neuroendocrine tumor, [68Ga]Pentixafor, CXCR4, PRRT, PET/CT,

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