Tumor Necrosis of Primary Malignancy Affects Survival and Outcome in Patients with Liver Metastases from Neuroendocrine Tumors

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Introduction: Reliable biomarkers represent a crucial unmet need in the management of neuroendocrine tumors. Tumor necrosis has been suggested to have a prognostic value in selected solid tumors but is not included in established WHO NET Grading Systems. However, little is known regarding the influence of tumor necrosis on tumor progression and prognosis in patients with liver metastasis from neuroendocrine tumors.

Aim(s): We analyzed retrospectively all patients (n = 55) with liver metastasis form neuroendocrine tumors of pancreas and gastro-intestinal tract, who underwent surgery between 2014 and 2017, for formation of tumor necrosis in primary cancer and hepatic metastases.

Materials and methods: Necrosis score was correlated with clinicopathologic characteristics, tumor recurrence and patients’ survival. Statistical analysis was performed with SPSS software.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Atanasov G

Authors: Atanasov G, Tsvetkova I, Strücker B, Andreou A, Bahra M,

Keywords: net, liver metastases, biomarker, tumor necrosis,