Tumour-Infiltrating Neutrophils Predict Poor Survival of Non-Functional Pancreatic Neuroendocrine Tumour Patients after Curative Resection

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Introduction: Non-functional pancreatic neuroendocrine tumours (NF-PanNETs) are steadily increasing in prevalence and present several clinical challenges.

Aim(s): This study retrospectively characterised the immune infiltrating profile in NF-PanNETs.

Materials and methods: Intratumoural, peritumoural stroma, and peritumoural normal pancreatic tissues from 109 NF-PanNET patients were evaluated by immunohistochemistry for nine immune cell infiltration: tumour-infiltrating neutrophils (TINs), CD11c+ dendrite cells, anti-NCR1+ NK cells, tumour-associated macrophages (TAMs), CD4+ and CD8+ T cells, CD45RO+ memory T cells, FOXP3+ regulatory T cells (Tregs) and CD20+ B cells.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Zhang W, Wang W,

Keywords: non-functional pancreatic neuroendocrine tumours, tumour immune microenvironment, tumour-infiltrating neutrophils, prognosis, predictors,