Two Cases Synchronous Atypical Parathyroid Adenomas and Papillary Thyroid Carcinoma

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Introduction: A literature review revealed a prevalence of approximately 3% of nonmedullary thyroid cancer, which was found in patients operated on for primary hyperparathyroidism (pHPT). Papillary thyroid carcinomas(PTC) is a malignant epithelial tumour. PTC represent up to 87% of all thyroid carcinomas. Atypical parathyroid adenoma(APA) are a subset of parathyroid neoplasms that exhibit some of the features of parathyroid carcinoma but lack unequivocal invasive growth. APA represents about 0,5-4% of cases of pHPT. As a group, they may be considered tumors of uncertain malignant potential.

Aim(s): We report two cases of a 63-year-old woman and 57- year-old man with a synchronous atypical parathyroid adenoma and papillary thyroid carcinoma.

Materials and methods: One of this patients had a classic symptoms of pHPT, including severe metabolic bone disease and renal disease, but another didn’t have. The mean preoperative calcium was 3,48 and 4,1 (normal range 2,12–2,6) mmol/l and a mean parathyroid hormone(PTH) of 1300 and 1533 (normal range 15–65) pg/ml, respectively. Thyroid ultrasound didn’t show a nodule with features of the thyroid carcinoma in both cases. The thyroid cancer was suspected after intraoperative revision.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Voronkova I, Mokrysheva N, Lapshina A, Gurevich L, Britvin T,

Keywords: papillary thyroid carcinomas, atypical parathyroid adenoma, primary hyperparathyroidism,