Variation Between Chromogranin A Assays in the Diagnosis of Gastric Carcinoid Type 1

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Introduction: Chromogranin A (CgA) is not very accurate for the diagnosis of gastric carcinoid type1 (GC1). Clinical interpretation of CgA results may be affected by the heterogeneity between CgA assays. The commercial CgA assay, DAKO (DAKO, Denmark A/S, Glostrup, Denmark) is an ELISA which recognizes a 23 kD C terminal fragment of CgA; the Imperial Supra-regional Assay Service radioimmunoassay (SAS Hammersmith Hospital, Imperial College, London) is a competitive radioimmunoassay raised against the whole pancreastatin molecule.

Aim(s): To compare CgA-DAKO and CgA-SAS to determine their accuracy in the diagnosis of GC1.

Materials and methods: Patients diagnosed with GC1 and available plasma CgA measurements according to two different assays (SAS, DAKO) were retrospectively reviewed. CgA values were ranked in four groups: 1. normal values 2. increase <2 upper normal limit (ULN) 3. increase between 2-5 ULN 4. increase >5 ULN

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Rossi R, Martin N, Garcia-Hernandez J, Mandair D, Mohmaduves M,

Keywords: gastric carcinoid type 1, chromogranin A,