Vimentin and E-cadherin Expression in Primary Neuroendocrine Tumors by Grade Abstract #988

Introduction: The prognostic evaluation of radically removed neuroendocrine tumors (NETs) represents an important issue. The cardinal tumor features can be studied as biomarkers.
Aim(s): To study cell adhesion and mesenchymal differentiation in primary NETs by grade.
Materials and methods: Consecutive surgically treated NETs were identified by retrospective archive search revealing 48 G1 and 22 G3 NETs of gastroenteropancreatic (44) and pulmonary (26) origin. Neuroendocrine markers (chromogranin A, synaptophysin, CD56), proliferation activity (Ki-67) and presence of E-cadherin (E-CAD) and vimentin (VIM) was detected by immunohistochemistry. Expression of E-CAD and VIM was scored semiquantitatively (0, negative; 1, weak; 2 moderate; 3 intense) and evaluated by the pattern as well. Descriptive statistics including 95% confidence interval (CI) calculation was performed.
Conference: 11th Annual ENETS Conference (2014)
Category: Biomarkers
Presenting Author: Andrejs Vanags
Keywords: NETs, vimentin, E-cadherin

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