Whole-Exome Sequencing (WES) of Samples from Patients (pts) Classified as Exceptional Responders (ER) vs Poor Responders (PO) to Targeted Therapies in Pancreatic Neuroendocrine Tumours (pNETs).

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Introduction: Sunitinib (SU) and everolimus (EVE) changed the treatment landscape for patients with well-differentiated pNETs. However, no predictive biomarkers have been established for these drug

Aim(s): We aimed to identify distinctive genomic alterations associated with benefit from SU and/or EVE treatment in patients with pNETs, by comparing ER to PO. Pts who achieved an objective radiological response together with those with a progression-free survival (PFS) beyond the median reported in the landmark trials were included in the ER group. Pts with a similar PFS to the placebo groups in the pivotal trials were classified as PO.

Materials and methods: Thirty-one pts were screened; following review of availability of the formalin-fixed paraffin embedded (FFPE) samples, 12 were found eligible to proceed with DNA extraction and sequencing. Paired DNA extracted from tumour (T) and non-T or blood was obtained. Two cases did not pass the quality check threshold for variant calling analysis (VCA).

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Barriuso J, Lamarca A, McNamara M, Manoharan P, Moghadam S,

Keywords: pNETs, WES, everolimus, sunitinib,